Lars2019 in The Journal of Headache and Pain.

Hypothalamus loses control in migraine

DOI: https://doi.org/10.1038/s41582- 021- 00563- z

[Section 1] Reduced hypothalamic control of the limbic system could be a cause of migraine attacks, according to new imaging research.

During the headache phase of migraine attacks, perfusion of the limbic system was high and hypothalamic connectivity to the limbic system was reduced relative to the interictal period.

The research supports the idea that the hypothalamus is central to migraine pathophysiology and suggests that control of limbic circuits could be a novel thera- peutic approach.

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2 Mechanisms

Acknowledgement A machine generated summary based on the work of Fyfe, Ian. 2021  in Nature Reviews Neurology.

The metabolic face of migraine—from pathophysiology to treatment